Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931701 | 0.80 | APLNR (0.43) | TDP1GABRA1GABRB2NFE2L2SMN1; SMN2 | |
| SCHEMBL30520123 | 0.78 | CYP3A4 (0.47) | TDP1GABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1410939 | 0.78 | CYP3A4 (0.47) | TDP1GABRA1GABRB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL21189180 | 0.77 | — | — | |
| SCHEMBL28344871 | 0.76 | TDP1 (0.39) | TDP1NFE2L2SMN1; SMN2HTTLMNA | |
| SCHEMBL23214427 | 0.76 | PLAU (0.52) | GABRA1GABRB2SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL3658777 | 0.76 | TRIM24 (0.34) | TDP1GABRA1GABRB2SMN1; SMN2HTT | |
| SCHEMBL9271729 | 0.73 | CYP3A4 (0.32) | TDP1MAPK1GABRA1GABRB2CYP3A4 | |
| SCHEMBL8691280 | 0.72 | CYP3A4 (0.45) | TDP1MAPK1GABRA1GABRB2NFE2L2 | |
| SCHEMBL28882238 | 0.72 | NFE2L2 (0.34) | TDP1NFE2L2SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105254623-A | SUBSTITUTED BENZAMIDES | HOFFMANN LA ROCHE | 2016-01-20 | — | — | CN | disclosed |