SCHEMBL28051944

SCHEMBL28051944

CC(Br)c1cccc2cc3cccc(C(C)Br)c3nc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.38
CYP1A2 P05177 3/20 0.38
ALDH1A1 P00352 3/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 3/20 0.36
KDM4E B2RXH2 3/20 0.36
CYP3A4 P08684 2/20 0.36
TSHR P16473 2/20 0.36
GLA P06280 2/20 0.36
HSD17B10 Q99714 1/20 0.36
PSMD14 O00487 1/20 0.35
COPS5 Q92905 1/20 0.35
LMNA P02545 2/20 0.35
TERT O14746 3/20 0.33
FAAH O00519 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRB1 P18505 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642704 0.76 PSMD14 (0.52) KDM4ECYP3A4TSHRPSMD14COPS5
SCHEMBL28005976 0.73 ALDH1A1 (0.45) P2RX7CYP1A2ALDH1A1CYP2C19CYP2C9
SCHEMBL10565450 0.73 ALDH1A1 (0.43) P2RX7CYP1A2ALDH1A1CYP2C19CYP2C9
SCHEMBL1186316 0.71 HPGD (0.50) CYP1A2ALDH1A1CYP2C19HPGDKDM4E
SCHEMBL11273383 0.70 UGT2B7 (0.41) P2RX7CYP1A2ALDH1A1CYP2C19CYP2C9
SCHEMBL2332847 0.70 ALDH1A1 (0.68) CYP1A2ALDH1A1CYP2C19CYP2C9TSHR
SCHEMBL7573609 0.69 ALDH1A1 (0.44) CYP1A2ALDH1A1CYP2C19HPGDKDM4E
SCHEMBL30566931 0.69 P2RX7 (0.45) P2RX7CYP1A2ALDH1A1CYP2C19CYP2C9
SCHEMBL1415318 0.69 P2RX7 (0.45) P2RX7CYP1A2ALDH1A1CYP2C19CYP2C9
SCHEMBL27328332 0.68 KDM4E (0.46) P2RX7ALDH1A1KDM4ETSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103502232-B Method for preparing alkanolamines obtained by homogeneously catalyzed alcohol amination BASF SE (DE) 2016-02-24 CN disclosed