Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 12/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799663 | 0.79 | ALDH1A1 (0.53) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL159802 | 0.78 | ALDH1A1 (0.46) | S1PR4NPC1MAPTRAB9AKDM4E | |
| SCHEMBL2638818 | 0.78 | NPC1 (0.47) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL187124 | 0.76 | CTSB (0.56) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL10025751 | 0.76 | NPC1 (0.51) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL31121580 | 0.76 | CTSB (0.56) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL20838493 | 0.74 | CCR1 (0.47) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL136263 | 0.73 | CTSB (0.53) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL30574931 | 0.73 | CTSB (0.53) | S1PR4NPC1MAPTLMNAHPGD | |
| SCHEMBL187354 | 0.73 | NPC1 (0.64) | S1PR4NPC1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209464-A | P2x7 modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |