Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556642 | 0.86 | ENPP2 (0.39) | ENPP2ERN1CDK1FFAR1FFAR4 | |
| SCHEMBL663531 | 0.79 | ENPP2 (0.39) | ENPP2ERN1CDK1FFAR1KDM4E | |
| SCHEMBL30694822 | 0.79 | ENPP2 (0.39) | ENPP2ERN1CDK1FFAR1KDM4E | |
| SCHEMBL1303380 | 0.79 | CDK1 (0.59) | ENPP2ERN1CDK1MMP3 | |
| SCHEMBL435376 | 0.77 | HTT (0.41) | ENPP2FFAR1FFAR4CYP11B1CYP11B2 | |
| SCHEMBL25457596 | 0.76 | LOXL2 (0.41) | ERN1CDK1 | |
| SCHEMBL12703942 | 0.76 | CYP4F2 (0.46) | ENPP2ERN1CDK1 | |
| SCHEMBL3854721 | 0.76 | LMNA (0.38) | ERN1CDK1NPC1LMNAMAPT | |
| SCHEMBL17149263 | 0.76 | IDO1 (0.41) | ERN1CDK1TDP1 | |
| SCHEMBL7593948 | 0.75 | TUBB1 (0.47) | ERN1KDM4ETDP1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541769-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2016-05-04 | — | — | CN | disclosed |
| CN-103664637-B | Be used for the treatment of ophthalmic diseases and disorderly alkynyl phenyl derivative compounds | ACUCELA INC. (US) | 2016-02-03 | — | — | CN | disclosed |