Crotonic Acid

Crotonic Acid

SCHEMBL28053102

C/C=C\C(=O)O.O=C(Nc1ccccc1-c1ccccc1)c1ccccc1

nearest known ligand 0.74

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.60
KMT2A Q03164 3/20 0.60
HPGD P15428 3/20 0.60
MEN1 O00255 2/20 0.60
CYP2C9 P11712 2/20 0.60
ABCG2 Q9UNQ0 1/20 0.52
KDM4E B2RXH2 5/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
MAPT P10636 4/20 0.50
HTT P42858 3/20 0.50
LMNA P02545 2/20 0.50
POLB P06746 2/20 0.50
TSHR P16473 2/20 0.49
PKM P14618 1/20 0.49
USP2 O75604 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12470503 0.86 ALDH1A1 (0.66) ALDH1A1KMT2AHPGDMEN1CYP2C9
SCHEMBL29434803 0.86 ALDH1A1 (0.66) ALDH1A1KMT2AHPGDMEN1CYP2C9
Ammonia Solution, Strong SCHEMBL29194251 0.85 ALDH1A1 (0.64) ALDH1A1KMT2AHPGDMEN1CYP2C9
Acrylic Acid SCHEMBL1505000 0.84 ALDH1A1 (0.57) ALDH1A1KMT2AHPGDMEN1CYP2C9
Propanol SCHEMBL28052966 0.81 ALDH1A1 (0.62) ALDH1A1KMT2AHPGDMEN1CYP2C9
SCHEMBL10144027 0.79 ALDH1A1 (0.74) ALDH1A1KMT2AHPGDMEN1CYP2C9
SCHEMBL29020526 0.78 MDM4 (0.67) ALDH1A1KMT2AHPGDMEN1CYP2C9
SCHEMBL6067716 0.78 HDAC1 (0.66) KMT2AHPGDMEN1CYP2C9ABCG2
SCHEMBL9695830 0.77 ALDH1A1 (0.64) ALDH1A1KMT2AHPGDCYP2C9KDM4E
SCHEMBL28442225 0.76 HDAC1 (0.61) ALDH1A1KMT2AHPGDMEN1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105330569-A Preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol TONGJING OPTOELECTRONICS TECHNOLOGY CO LTD 2016-02-17 CN disclosed