Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100451 | 0.85 | TSHR (0.51) | TSHRMAPK8SIRT2ALDH1A1KDM4E | |
| SCHEMBL28185434 | 0.85 | PLA2G2A (0.49) | TSHRSIRT2PARP1PLA2G10PLA2G2A | |
| SCHEMBL4182429 | 0.84 | ALDH1A1 (0.45) | TSHRMAPK8SIRT2ALDH1A1KDM4E | |
| SCHEMBL27913154 | 0.80 | MAPK8 (0.43) | MAPK8SIRT2ALDH1A1KDM4EHPGD | |
| SCHEMBL30029537 | 0.77 | RPS6KB1 (0.43) | MAPK8SIRT2PARP1PARP10 | |
| SCHEMBL4523553 | 0.76 | MYC (0.48) | TSHRALDH1A1KDM4EHPGDGAA | |
| SCHEMBL10727676 | 0.75 | TSHR (0.54) | TSHRALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL4908158 | 0.73 | TSHR (0.72) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Diethylamine SCHEMBL8601287 | 0.73 | PARP1 (0.41) | TSHRMAPK8ALDH1A1KDM4EHPGD | |
| SCHEMBL4848573 | 0.73 | TSHR (0.53) | TSHRALDH1A1KDM4EHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294597-A | Benzothiazine derivative, and synthetic method and application thereof | UNIV EAST CHINA NORMAL | 2016-02-03 | — | — | CN | claimed |
| CN-105294597-A | Benzothiazine derivative, and synthetic method and application thereof | UNIV EAST CHINA NORMAL | 2016-02-03 | — | — | CN | disclosed |