Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053690 | 1.00 | PARP10 (0.39) | PARP10PARP1PTGS1PTGS2PDE2A | |
| SCHEMBL4734628 | 0.80 | PARP1 (0.44) | PARP10PARP1DPP4 | |
| SCHEMBL24959998 | 0.78 | PARP1 (0.42) | PARP10PARP1DPP4 | |
| SCHEMBL28053612 | 0.77 | ROCK2 (0.44) | PARP10PARP1PTGS1PTGS2PDE2A | |
| SCHEMBL28053615 | 0.77 | ROCK2 (0.44) | PARP10PARP1PTGS1PTGS2PDE2A | |
| SCHEMBL28388304 | 0.74 | CHEK2 (0.39) | PARP10PARP1HTR1BHTR1AHTR1D | |
| SCHEMBL25466542 | 0.73 | HSD17B10 (0.44) | PARP10PARP1DPP4 | |
| SCHEMBL16117008 | 0.72 | CXCR3 (0.43) | PDE2ADPP4DPP7HTR2C | |
| SCHEMBL3691250 | 0.70 | SLC9A1 (0.45) | PARP10PARP1DPP4 | |
| SCHEMBL18451253 | 0.69 | PARP1 (0.43) | PARP10PARP1PDE2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103797010-B | As the azetidinyl phenyl of JAK inhibitor, pyridyl or pyrazinyl carboxamides derivatives | INCYTE HOLDINGS CORP. (US) | 2016-02-24 | — | — | CN | disclosed |