Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 13/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29753282 | 0.87 | ALDH1A1 (0.78) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL17411235 | 0.86 | SIRT6 (0.81) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL17410978 | 0.85 | SIRT6 (0.74) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL1230074 | 0.84 | ALDH1A1 (0.77) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL12840924 | 0.84 | LMNA (0.77) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL17411232 | 0.84 | ALDH1A1 (0.68) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL18812853 | 0.83 | ALDH1A1 (0.64) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL520963 | 0.83 | LMNA (0.75) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL29788578 | 0.83 | ALDH1A1 (1.00) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL6367942 | 0.83 | ALDH1A1 (1.00) | ALDH1A1LMNASIRT6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-105384694-A | Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |