Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21419553 | 0.88 | CYP1B1 (0.45) | KDM4ELMNATP53MAPK1SMN1; SMN2 | |
| SCHEMBL19176752 | 0.88 | CYP1B1 (0.45) | KDM4ELMNATP53MAPK1SMN1; SMN2 | |
| SCHEMBL1275809 | 0.88 | CYP1B1 (0.45) | KDM4ELMNATP53MAPK1SMN1; SMN2 | |
| Bicarbonate SCHEMBL2319198 | 0.84 | TRPA1 (0.46) | OPRL1CYP1B1CYP19A1TRPA1 | |
| SCHEMBL20365061 | 0.82 | CYP1B1 (0.44) | LMNATP53MAPK1SMN1; SMN2OPRL1 | |
| SCHEMBL485615 | 0.78 | MGLL (0.44) | LMNATP53MAPK1SMN1; SMN2CYP1B1 | |
| SCHEMBL3828808 | 0.76 | CYP1B1 (0.40) | LMNATP53MAPK1SMN1; SMN2CYP1B1 | |
| SCHEMBL1766181 | 0.75 | PTGS1 (0.36) | TDP1CYP1A2HIF1AOPRL1OPRM1 | |
| SCHEMBL18279974 | 0.75 | TRPA1 (0.40) | CYP1B1TRPA1 | |
| SCHEMBL28952214 | 0.73 | MGLL (0.37) | LMNATP53MAPK1SMN1; SMN2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105267233-A | Compositions and methods for inhibiting expression of Eg5 and VEGF genes | ALNYLAM PHARMACEUTICALS INC | 2016-01-27 | — | — | CN | disclosed |