Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45794 | 0.86 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL20661164 | 0.83 | PTGS1 (0.35) | PTGS1PTGS2ALDH1A1CYP1A2HPGD | |
| SCHEMBL19326880 | 0.77 | PTGS1 (0.32) | PTGS1PTGS2ALDH1A1CYP1A2HPGD | |
| Bicarbonate SCHEMBL2319198 | 0.76 | TRPA1 (0.46) | PTGS1PTGS2TRPA1OPRL1 | |
| Cyclohexane SCHEMBL3760865 | 0.76 | LMNA (0.50) | SIGMAR1ITGB3ITGA2BNAAAALDH1A1 | |
| Monoethanolamine SCHEMBL28054142 | 0.75 | TDP1 (0.40) | GLATDP1TRPA1BACE1CYP1A2 | |
| SCHEMBL4426720 | 0.75 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL19176752 | 0.73 | CYP1B1 (0.45) | TRPA1BACE1ALDH1A1HPGDBLM | |
| SCHEMBL1275809 | 0.73 | CYP1B1 (0.45) | TRPA1BACE1ALDH1A1HPGDBLM | |
| SCHEMBL21419553 | 0.73 | CYP1B1 (0.45) | TRPA1BACE1ALDH1A1HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249873-B1 | CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO A POLYANION FOR THE TREATMENT OF AIDS | PASTEUR INSTITUT (FR) | 2016-11-16 | — | — | EP | claimed |
| EP-2478049-B1 | A POLYMER SUPPORT | UNIV CAPE TOWN (ZA) | 2015-02-25 | — | — | EP | claimed |
| EP-1813614-B1 | Cytotoxic agents comprising new tomaymycin derivatives | SANOFI SA (FR) | 2011-10-05 | — | — | EP | claimed |
| US-20240091315-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | AMUNIX PHARMACEUTICALS, INC. | 2024-03-21 | — | — | US | disclosed |
| CN-112999362-B | Stable antibody drug coupling and preparation method and application thereof | 启德医药科技（苏州）有限公司 | 2023-11-14 | — | — | CN | disclosed |
| US-20210322518-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | AMUNIX PHARMACEUTICALS, INC. | 2021-10-21 | — | — | US | disclosed |
| US-10172953-B2 | XTEN conjugate compositions and methods of making same | AMUNIX OPERATING INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20150037359-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | Amunix Operating, Inc. (US) | 2015-02-05 | — | — | US | disclosed |
| EP-2819788-A2 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | Amunix Operating Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130683-A2 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | AMUNIX OPERATING INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013130684-A1 | XTEN-FOLATE CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | AMUNIX OPERATING INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| EP-2320942-A2 | DIAGNOSTIC ANTIBODY ASSAY | Probiodrug AG (DE) | 2011-05-18 | — | — | EP | disclosed |
| EP-2018559-A1 | FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS. APPLICATION TO THE HIGH-DENSITY LABELLING OF CELL MEMBRANES | Centre National de la Recherche Scientifique (CNRS) (FR) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007122259-A1 | FUNCTIONALIZATION OF GOLD NANOPARTICLES WITH ORIENTED PROTEINS. APPLICATION TO THE HIGH-DENSITY LABELLING OF CELL MEMBRANES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150037359-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | XPA, TXLNA, NGLY1 | PTGS1 3385/4885PTGS2 3374/4885GLA 856/4885 |
| US-10172953-B2 | XTEN conjugate compositions and methods of making same | XPA, TXLNA, NGLY1 | PTGS1 3385/4885PTGS2 3374/4885GLA 856/4885 |
| US-20210322518-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | XPA, TXLNA, NGLY1 | PTGS1 3385/4885PTGS2 3374/4885GLA 856/4885 |
| US-20240091315-A1 | XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME | XPA, TXLNA, NGLY1 | PTGS1 3385/4885PTGS2 3374/4885GLA 856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.