Urea

Urea

SCHEMBL28054623

NC(N)=O.c1ccc(COCc2ccccc2)cc1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.71
ALDH1A1 P00352 3/20 0.54
PARP10 Q53GL7 1/20 0.53
IDO1 P14902 1/20 0.52
KMT2A Q03164 2/20 0.52
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A3 Q01959 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
KDM4E B2RXH2 1/20 0.52
POLB P06746 1/20 0.52
SLC1A1 P43005 3/20 0.51
AGXT P21549 1/20 0.50
ALOX5 P09917 1/20 0.49
SLC1A3 P43003 2/20 0.48
SLC1A2 P43004 2/20 0.48
MEN1 O00255 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL119806 0.95 TSHR (0.71) TSHRALDH1A1PARP10IDO1KMT2A
Hydroxyamine SCHEMBL1680424 0.87 TSHR (0.83) TSHRALDH1A1IDO1MAPK1L3MBTL1
Benzyl Carbamate SCHEMBL7386720 0.87 TSHR (0.60) TSHRALDH1A1PARP10KMT2AMAPK1
Hydrogen Peroxide SCHEMBL28758135 0.87 TSHR (0.94) TSHRALDH1A1IDO1KMT2AMAPK1
Acetone SCHEMBL28740549 0.86 TSHR (0.71) TSHRALDH1A1KMT2AMAPK1L3MBTL1
Acetic Acid SCHEMBL28710458 0.86 TSHR (0.71) TSHRALDH1A1KMT2AMAPK1L3MBTL1
Acetic Acid SCHEMBL4466285 0.86 TSHR (0.71) TSHRALDH1A1KMT2AMAPK1L3MBTL1
SCHEMBL203767 0.85 TSHR (0.56) TSHRALDH1A1PARP10IDO1KMT2A
SCHEMBL27380 0.84 TSHR (1.00) TSHRALDH1A1IDO1SLC6A2SLC6A3
SCHEMBL5311581 0.84 TSHR (1.00) TSHRALDH1A1IDO1SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102656172-B 8-oxodihydropurine derivatives DAINIPPON SUMITOMO PHARMA CO.,LTD. (JP) 2016-03-23 CN disclosed