Acetic Acid

Acetic Acid

SCHEMBL4466285

CC(=O)O.c1ccc(COCc2ccccc2)cc1

nearest known ligand 0.71

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.71
ALDH1A1 P00352 6/20 0.65
MAOB P27338 3/20 0.53
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A3 Q01959 1/20 0.52
KMT2A Q03164 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.50
BRD4 O60885 1/20 0.49
SLC1A1 P43005 1/20 0.47
LMNA P02545 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28710458 1.00 TSHR (0.71) TSHRALDH1A1MAOBMAPK1L3MBTL1
Acetone SCHEMBL28740549 0.95 TSHR (0.71) TSHRALDH1A1MAOBMAPK1L3MBTL1
SCHEMBL28301231 0.87 TSHR (0.83) TSHRALDH1A1MAPK1L3MBTL1SLC6A2
Hydrogen Peroxide SCHEMBL28758135 0.87 TSHR (0.94) TSHRALDH1A1MAPK1L3MBTL1SLC6A2
Methacrylic Acid SCHEMBL30425451 0.87 TSHR (0.60) TSHRALDH1A1MAOBMAPK1L3MBTL1
Propylene Glycol SCHEMBL15618691 0.87 TSHR (0.54) TSHRALDH1A1MAOBMAPK1L3MBTL1
SCHEMBL11145254 0.86 TSHR (0.71) TSHRALDH1A1MAOBSLC6A2SLC6A3
Urea SCHEMBL28054623 0.86 TSHR (0.71) TSHRALDH1A1MAPK1L3MBTL1SLC6A2
Carbamic Acid SCHEMBL119806 0.86 TSHR (0.71) TSHRALDH1A1MAPK1L3MBTL1SLC6A2
Acetic Acid SCHEMBL28567289 0.86 ALDH1A1 (0.55) TSHRALDH1A1MAOBMAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116368146-A Novel ligands for asialoglycoprotein receptors 赛诺菲 2023-06-30 CN disclosed
US-20090124737-A1 ACRYLIC PLASTISOL VISCOSITY REDUCERS EASTMAN CHEMICAL COMPANY (US) 2009-05-14 US disclosed