Methane

Methane

SCHEMBL28055041

C.O=C(Cl)C(Cl)c1cccc2ccccc12

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
CYP1A2 P05177 1/20 0.47
HPGD P15428 1/20 0.43
HTT P42858 1/20 0.43
HDAC8 Q9BY41 2/20 0.42
MMP3 P08254 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
ACP3 P15309 4/20 0.41
CMA1 P23946 2/20 0.41
CTSG P08311 1/20 0.41
GAA P10253 2/20 0.39
LMNA P02545 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27749398 0.98 CYP1A2 (0.48) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL3594861 0.83 ALDH1A1 (0.49) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL28564523 0.79 ALDH1A1 (0.49) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL28055007 0.78 ALDH1A1 (0.47) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL10821051 0.78 ALDH1A1 (0.47) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL2986085 0.78 ALDH1A1 (0.47) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL11469390 0.77 KMT2A (0.45) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL11544705 0.75 ALDH1A1 (0.44) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL6926862 0.75 KMT2A (0.43) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD
SCHEMBL5610170 0.74 ALDH1A1 (0.61) ALDH1A1CYP2C9CYP2C19CYP1A2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105699582-B HPLC detection method of 3-aminopiperidine isomer 河北科技大学 2017-05-03 CN disclosed
CN-105699582-A HPLC detection method of 3-aminopiperidine isomer 河北科技大学 2016-06-22 CN disclosed