Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.49 |
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16382749 | 0.87 | BTK (0.48) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL28321329 | 0.87 | BTK (0.48) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL16336702 | 0.85 | JAK1 (0.49) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL16336487 | 0.81 | BTK (0.67) | JAK2JAK1BTK | |
| SCHEMBL19019034 | 0.81 | JAK1 (0.52) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL3436375 | 0.78 | HSD11B1 (0.54) | JAK2JAK1KDM4EMAPTTHRB | |
| SCHEMBL28321303 | 0.77 | GPR119 (0.42) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL27393884 | 0.77 | GPR119 (0.53) | KDM4EMAPTTHRBPDE4BGPR119 | |
| SCHEMBL14143336 | 0.76 | JAK1 (0.57) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL14181451 | 0.76 | KDM4E (0.63) | JAK2JAK1KDM4EPDE4BHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-A | Primary carboxamides as BIK inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | disclosed |