Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | TYK2 | P29597 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16382749 | 0.92 | BTK (0.48) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL16336702 | 0.90 | JAK1 (0.49) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL28055972 | 0.87 | JAK2 (0.49) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL16336487 | 0.86 | BTK (0.67) | BTKJAK2JAK1 | |
| SCHEMBL19019034 | 0.79 | JAK1 (0.52) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL4939245 | 0.78 | GPR119 (0.52) | JAK2JAK1HPGDSMEN1KMT2A | |
| SCHEMBL31210541 | 0.77 | GOT1 (0.47) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL6606633 | 0.76 | GPR119 (0.53) | HPGDSMEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL25104515 | 0.75 | HPGD (0.46) | JAK2JAK1TYK2JAK3HPGDS | |
| SCHEMBL14143336 | 0.75 | JAK1 (0.57) | JAK2JAK1TYK2JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105530932-B | Primary formamide as BTK inhibitor | 艾伯维公司 | 2019-09-27 | — | — | CN | disclosed |