Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21487604 | 0.79 | PDE2A (0.33) | PDE2AEPHX2 | |
| SCHEMBL28056275 | 0.79 | GRIN2B (0.36) | PDE2AEPHX2SCN9A | |
| SCHEMBL15679418 | 0.79 | PDE2A (0.36) | PDE2AEPHX2NOS3NOS1NOS2 | |
| SCHEMBL31143077 | 0.76 | LMNA (0.39) | — | |
| SCHEMBL4218979 | 0.72 | ALB (0.39) | PDE2AEPHX2MPLKCNN4SCN9A | |
| SCHEMBL14553824 | 0.72 | PDE2A (0.36) | PDE2AEPHX2NOS3NOS1NOS2 | |
| SCHEMBL102976 | 0.71 | ERN1 (0.39) | — | |
| SCHEMBL25371124 | 0.71 | MPL (0.40) | MPLAPPSCN9A | |
| SCHEMBL28083133 | 0.70 | MPL (0.45) | MPLALOX5APFEN1SCN9A | |
| SCHEMBL102339 | 0.69 | KIF11 (0.41) | MPLIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431427-B | Novel PDE 4 inhibitor | 明治制果药业株式会社 | 2017-12-08 | — | — | CN | disclosed |
| CN-105431427-A | Novel PDE4 inhibitor | MEIJI SEIKA PHARMA CO LTD | 2016-03-23 | — | — | CN | disclosed |