Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | S100A9 | P06702 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083345 | 0.81 | GRIN2B (0.35) | GRIN2BSLC1A5SCN9AKMONOTUM | |
| SCHEMBL28056272 | 0.79 | PDE2A (0.41) | SCN9APDE2AEPHX2 | |
| SCHEMBL15679418 | 0.78 | PDE2A (0.36) | SCN9APDE2AEPHX2 | |
| SCHEMBL21487604 | 0.78 | PDE2A (0.33) | SLC1A5PDE2AEPHX2 | |
| SCHEMBL29917977 | 0.76 | KMO (0.42) | SCN9AKMOAKR1C2AKR1C1EPHX2 | |
| SCHEMBL28056270 | 0.74 | PDE2A (0.33) | GRIN2BSLC1A5KMOAKR1C2AKR1C1 | |
| SCHEMBL29778856 | 0.73 | GRIA1 (0.42) | GRIN2B | |
| SCHEMBL21603543 | 0.73 | GRIA1 (0.42) | GRIN2B | |
| SCHEMBL28056179 | 0.71 | HTR3E (0.44) | NOTUM | |
| SCHEMBL14553824 | 0.70 | PDE2A (0.36) | SCN9APDE2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431427-B | Novel PDE 4 inhibitor | 明治制果药业株式会社 | 2017-12-08 | — | — | CN | disclosed |
| CN-105431427-A | Novel PDE4 inhibitor | MEIJI SEIKA PHARMA CO LTD | 2016-03-23 | — | — | CN | disclosed |