Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749946 | 0.79 | RIPK1 (0.47) | RIPK1CTSKLMNAPOLBCCR2 | |
| SCHEMBL15083020 | 0.75 | MMP1 (0.45) | RIPK1 | |
| SCHEMBL15894960 | 0.75 | MMP1 (0.45) | RIPK1 | |
| SCHEMBL14712207 | 0.74 | RIPK1 (0.42) | RIPK1CTSK | |
| SCHEMBL20047507 | 0.73 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL23175981 | 0.72 | RIPK1 (0.42) | RIPK1LMNAPOLB | |
| SCHEMBL15895098 | 0.72 | RIPK1 (0.42) | RIPK1LMNAPOLB | |
| SCHEMBL19449732 | 0.72 | RIPK1 (0.42) | RIPK1LMNAPOLBCCR2 | |
| SCHEMBL25748849 | 0.72 | RIPK1 (0.42) | RIPK1LMNAPOLBCCR2 | |
| SCHEMBL26428610 | 0.72 | RIPK1 (0.42) | RIPK1LMNAPOLBCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574801-B | Substituted aminopropionic acid derivatives as enkephalinase inhibitors | NOVARTIS AG (CH) | 2016-04-27 | — | — | CN | disclosed |
| CN-103896796-B | As the alanine derivatives of the replacement of enkephalinase inhibitor | NOVARTIS AG (CH) | 2016-04-27 | — | — | CN | disclosed |