Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triflupromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.87 |
| ▸ | TP53 | P04637 | 6/20 | 0.87 |
| ▸ | HTR1A | P08908 | 5/20 | 0.87 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.87 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.87 |
| ▸ | DRD1 | P21728 | 4/20 | 0.87 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.87 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.87 |
| ▸ | DRD3 | P35462 | 4/20 | 0.87 |
| ▸ | THPO | P40225 | 4/20 | 0.87 |
| ▸ | MTOR | P42345 | 4/20 | 0.87 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.87 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.87 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.87 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triflupromazine SCHEMBL44085 | 0.93 | CYP1A2 (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Triflupromazine SCHEMBL32668886 | 0.93 | CYP1A2 (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Triflupromazine SCHEMBL317144 | 0.92 | LMNA (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Triflupromazine SCHEMBL29419087 | 0.92 | LMNA (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Triflupromazine SCHEMBL30903901 | 0.92 | LMNA (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Triflupromazine SCHEMBL317145 | 0.91 | CYP1A2 (0.95) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Chlorpromazine SCHEMBL8321 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Chlorpromazine SCHEMBL29358018 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Chlorpromazine SCHEMBL29367385 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP2D6TP53HTR1AADRA2A | |
| Fluphenazine SCHEMBL19817113 | 0.89 | LMNA (0.76) | CYP1A2CYP2D6TP53HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764502-A | Combination methods for improving the therapeutic benefit of bisantrene and analogs and derivatives thereof | 现代化制药公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105764501-A | Compositions for improving the therapeutic benefit of bisantrene | 现代化制药公司 | 2016-07-13 | — | — | CN | disclosed |