Triflupromazine

Triflupromazine

SCHEMBL44085

CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DRD2

The experimentally established mechanism targets of Triflupromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 known ✓ P14416 6/20 0.71
CYP1A2 P05177 8/20 1.00
CYP2D6 P10635 8/20 1.00
TP53 P04637 7/20 1.00
HTR1A P08908 7/20 1.00
ADRA2A P08913 6/20 1.00
CHRM1 P11229 6/20 1.00
DRD1 P21728 6/20 1.00
SLC6A2 P23975 6/20 1.00
SLC6A4 P31645 6/20 1.00
ADRA1A P35348 6/20 1.00
DRD3 P35462 6/20 1.00
KCNH2 Q12809 6/20 1.00
MAPK1 P28482 6/20 1.00
THPO P40225 5/20 1.00
MTOR P42345 5/20 1.00
CHRM2 P08172 5/20 1.00
OPRM1 P35372 5/20 1.00
SLC6A3 Q01959 5/20 1.00
TSHR P16473 4/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triflupromazine SCHEMBL32668886 1.00 CYP1A2 (1.00) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL30903901 0.99 LMNA (1.00) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL317144 0.99 LMNA (1.00) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL29419087 0.99 LMNA (1.00) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL317145 0.98 CYP1A2 (0.95) CYP1A2CYP2D6TP53HTR1AADRA2A
SCHEMBL7750160 0.95 TP53 (0.91) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL28057425 0.93 CYP1A2 (0.87) CYP1A2CYP2D6TP53HTR1AADRA2A
SCHEMBL7346761 0.93 TP53 (0.86) CYP1A2CYP2D6TP53HTR1AADRA2A
SCHEMBL23353457 0.92 TP53 (0.85) CYP1A2CYP2D6TP53HTR1AADRA2A
Triflupromazine SCHEMBL9055400 0.92 TP53 (0.85) CYP1A2CYP2D6TP53HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8154 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714452-A1 METHODS FOR TREATING SARS COV-2 INFECTIONS Gilead Sciences, Inc. (US) 2026-03-25 EP claimed
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
US-20260034065-A1 EXTENDED RELEASE PHARMACEUTICAL FORMULATION DOUGLAS PHARMACEUTICALS LTD (NZ) 2026-02-05 US claimed
EP-4658278-A1 SELECTIVE FIASMA TREATMENT Valo Health, Inc. (US) 2025-12-10 EP claimed
US-12472146-B2 Extended release pharmaceutical formulation DOUGLAS PHARMACEUTICALS, LTD. (NZ) 2025-11-18 US claimed
US-20250295671-A1 Hazardous Agent Injection System ANTARES PHARMA, INC. (US) 2025-09-25 US claimed
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 EP claimed
US-12357642-B2 Hazardous agent injection system ANTARES PHARMA, INC. (US) 2025-07-15 US claimed
US-12350379-B2 Extended release pharmaceutical formulation and methods of treatment DOUGLAS PHARMACETICALS LTD (NZ) 2025-07-08 US claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 US claimed
WO-1987006119-A1 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD AL SIOUFI HABIB 1987-10-22 WO claimed
EP-0174342-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. UNIV FLORIDA (US) 1986-03-19 EP claimed
WO-1985003937-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1985-09-12 WO claimed
US-4536403-A WITH CARISOPRODOL ROOKS J F GIRARD 1985-08-20 US claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 EP claimed
US-4478822-A Drug delivery system utilizing thermosetting gels MERCK & CO., INC. (US) 1984-10-23 US claimed
US-4474752-A DIAMINE MODIFIED POLYOXYETHYLENE-POLYOXYPROPYLENE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4407800-A TRYPANOCIDES UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) 1983-10-04 US claimed
US-4249003-A Process for polycyclic amines AKTIEBOLAGET LEO (SE) 1981-02-03 US claimed
US-4175119-A Composition and method to prevent accidental and intentional overdosage with psychoactive drugs PORTER GARRY L 1979-11-20 US claimed