Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triflupromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.69 |
| ▸ | LMNA | P02545 | 11/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | TP53 | P04637 | 7/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | GMNN | O75496 | 4/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.98 |
| ▸ | HTR1A | P08908 | 7/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.98 |
| ▸ | DRD1 | P21728 | 6/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triflupromazine SCHEMBL317144 | 1.00 | LMNA (1.00) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL30903901 | 1.00 | LMNA (1.00) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL32668886 | 0.99 | CYP1A2 (1.00) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL44085 | 0.99 | CYP1A2 (1.00) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL317145 | 0.96 | CYP1A2 (0.95) | LMNAMAPTTP53NPSR1TDP1 | |
| SCHEMBL7750160 | 0.94 | TP53 (0.91) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL28057425 | 0.92 | CYP1A2 (0.87) | LMNAMAPTTP53NPSR1TDP1 | |
| SCHEMBL7346761 | 0.91 | TP53 (0.86) | LMNAMAPTTP53NPSR1TDP1 | |
| SCHEMBL23353457 | 0.91 | TP53 (0.85) | LMNAMAPTTP53NPSR1TDP1 | |
| Triflupromazine SCHEMBL9055400 | 0.91 | TP53 (0.85) | LMNAMAPTTP53NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233573-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO (JP) | 2023-07-27 | — | — | US | claimed |
| CN-218901824-U | Efficient mixing equipment for producing flumioxazin | 内蒙古世杰化工有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-114828630-A | Herbicidal composition | UPL有限责任公司 | 2022-07-29 | — | — | CN | claimed |
| WO-2022124342-A1 | AGENT FOR CANCER THERAPY, AND SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF | 国立大学法人 岡山大学 | 2022-06-16 | — | — | WO | claimed |
| CN-122012456-A | Cutinase variants and polynucleotides encoding same | 诺维信公司 | 2026-05-12 | — | — | CN | disclosed |
| EP-4617666-A1 | BIOMARKERS FOR GASTROINTESTINAL DISEASES IN ANIMALS | Impextraco NV (BE) | 2025-09-17 | — | — | EP | disclosed |
| EP-4530598-A1 | BIOMARKERS FOR GASTROINTESTINAL DISEASES IN ANIMALS | Impextraco NV (BE) | 2025-04-02 | — | — | EP | disclosed |
| US-20240285643-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A SEVERE INFLUENZA CONDITION | SHIONOGI & CO (JP) | 2024-08-29 | — | — | US | disclosed |
| US-20240274877-A1 | ELECTROLYTE, SECONDARY BATTERY, BATTERY MODULE, BATTERY PACK, AND ELECTRIC APPARATUS | CONTEMPORARY AMPEREX TECHNOLOGY (HONG KONG) LIMITED (CN) | 2024-08-15 | — | — | US | disclosed |
| US-20240238306-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A COMPLICATION RISK FACTOR | SHIONOGI & CO (JP) | 2024-07-18 | — | — | US | disclosed |
| EP-3080254-B1 | CUTINASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME | NOVOZYMES AS (DK) | 2024-05-15 | — | — | EP | disclosed |
| CN-113735950-B | Nucleic acid molecules for imparting insecticidal properties in plants | 先正达参股股份有限公司 | 2024-03-19 | — | — | CN | disclosed |
| WO-2022124342-A1 | AGENT FOR CANCER THERAPY, AND SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF | 国立大学法人 岡山大学 | 2022-06-16 | — | — | WO | disclosed |
| US-20220142162-A1 | HERBICIDAL COMPOSITIONS | SYNGENTA CROP PROTECTION AG (CH) | 2022-05-12 | — | — | US | disclosed |
| WO-2022095816-A1 | TERNARY HERBICIDAL COMPOSITION COMPRISING CARBOXYLIC ACID DERIVATIVE-SUBSTITUTED OXYIMINOARYL COMPOUND AND USE THEREOF | 青岛清原化合物有限公司 | 2022-05-12 | — | — | WO | disclosed |
| CN-114449894-A | Herbicide combinations | UPL巴西工业和农业股份公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-114403136-A | Mixed solvent mainly comprising N, N-dimethylcaproamide, and preparation method and application thereof | 祺农化工科技(上海)有限公司 | 2022-04-29 | — | — | CN | disclosed |
| WO-2022068377-A1 | BINARY HERBICIDAL COMPOSITION AND USE THEREOF | 青岛清原化合物有限公司 | 2022-04-07 | — | — | WO | disclosed |
| CN-109310082-B | Timed release granular agrochemical composition and process for producing the same | 拜耳农作物科学股份公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114072388-A | Plant growth regulator and method for promoting plant growth | 株式会社吴羽 | 2022-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220142162-A1 | HERBICIDAL COMPOSITIONS | PPOX, DDT, HPD | DRD2 2342/4885LMNA 4732/4885MAPT 3851/4885 |
| US-20240285643-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A SEVERE INFLUENZA CONDITION | NEU4, IDO1, CYP3A4 | DRD2 2085/4885LMNA 970/4885MAPT 4850/4885 |
| US-20230233573-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | PNPO, IDO1, PDXK | DRD2 2802/4885LMNA 1181/4885MAPT 4290/4885 |
| US-20240274877-A1 | ELECTROLYTE, SECONDARY BATTERY, BATTERY MODULE, BATTERY PACK, AND ELECTRIC APPARATUS | LAGE3, SLC9B2, SLC26A3 | DRD2 1578/4885LMNA 1442/4885MAPT 1913/4885 |
| US-20240238306-A1 | TREATING INFLUENZA USING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF IN A SUBJECT HAVING INFLUENZA AND A COMPLICATION RISK FACTOR | PNPO, PLPBP, CYP2C19 | DRD2 3984/4885LMNA 1729/4885MAPT 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.