Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27796415 | 0.89 | ATR (0.47) | ATRGRM5ALDH1A1GABRA1GABRG2 | |
| SCHEMBL2036467 | 0.84 | MAPKAPK2 (0.42) | PLAUGRM5ALDH1A1MAPKAPK2DHFR | |
| SCHEMBL19360576 | 0.84 | CNR1 (0.34) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25399004 | 0.81 | NPSR1 (0.47) | ATRPLAUGRM5ALDH1A1KDM4E | |
| SCHEMBL7406650 | 0.76 | GABRA1 (0.37) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15684383 | 0.76 | GABRA5 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17202771 | 0.75 | CA12 (0.33) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL28251522 | 0.74 | CA12 (0.35) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17318254 | 0.74 | USP30 (0.40) | MAPKAPK2 | |
| SCHEMBL29512310 | 0.73 | PLAU (0.40) | PLAUALDH1A1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950479-A | Solid forms of condensed pyrazines as SYK inhibitors | 克洛诺斯生物股份有限公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-106572999-A | SYK inhibitors | 吉利德科学公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-105555780-A | Syk inhibitors | GILEAD SCIENCES INC | 2016-05-04 | — | — | CN | disclosed |