Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059095 | 0.92 | MAPK14 (0.58) | MAPK14ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL28059008 | 0.88 | MAPK14 (0.54) | MAPK14ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL28059005 | 0.85 | MAPT (0.54) | MAPK14ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL28059091 | 0.84 | MAPK14 (0.53) | MAPK14ALOX15TSHRCASP1NPSR1 | |
| SCHEMBL28059099 | 0.71 | MAPK14 (0.48) | MAPK14NPSR1MAPK13MAPK12MAPK11 | |
| SCHEMBL48415 | 0.70 | PIK3CD (0.61) | MEN1ALDH1A1KMT2A | |
| SCHEMBL5051520 | 0.69 | GRM4 (0.51) | MAPK14MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL28059092 | 0.69 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11IKBKB | |
| SCHEMBL28059094 | 0.69 | KMT2A (0.52) | MAPK14NPSR1KDRMAPK9MEN1 | |
| SCHEMBL4899528 | 0.68 | RAB9A (0.53) | NPSR1MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | claimed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |