Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059009 | 0.89 | MEN1 (0.46) | PIK3CAL3MBTL1RAB9AMEN1KMT2A | |
| SCHEMBL28059057 | 0.88 | MAPT (0.55) | PIK3CAPIK3CGPIK3CDPIK3CBRAB9A | |
| SCHEMBL28826932 | 0.77 | XIAP (0.47) | PIK3CAPIK3CGPIK3CDPIK3CBPI4KB | |
| SCHEMBL28059018 | 0.74 | MEN1 (0.56) | PIK3CAPIK3CGPIK3CDPIK3CBRAB9A | |
| SCHEMBL28059095 | 0.70 | MAPK14 (0.58) | RAB9AMEN1KMT2ANPC1KDM4E | |
| SCHEMBL28059005 | 0.70 | MAPT (0.54) | L3MBTL1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28059091 | 0.70 | MAPK14 (0.53) | PIK3CAPIK3CGPIK3CDPIK3CBKDM4E | |
| SCHEMBL28059008 | 0.69 | MAPK14 (0.54) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 | |
| SCHEMBL20981664 | 0.67 | L3MBTL1 (0.82) | L3MBTL1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5047340 | 0.67 | GAA (0.58) | PIK3CAPIK3CGPIK3CDPIK3CBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | claimed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |