Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059124 | 0.84 | KDM4E (0.43) | KDM4EALDH1A1ACHEHSP90AA1HSP90AB1 | |
| SCHEMBL5797268 | 0.76 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL31518606 | 0.76 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| Hydrochloric Acid SCHEMBL5375047 | 0.74 | KDM4E (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| Hydrochloric Acid SCHEMBL7868157 | 0.74 | KDM4E (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL11113633 | 0.74 | ADRB1 (0.61) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL4501470 | 0.72 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL7604060 | 0.72 | ADRB1 (0.64) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL5758330 | 0.72 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 | |
| SCHEMBL573580 | 0.72 | ADRB1 (0.59) | ADRB1KDM4EALDH1A1ACHEROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814051-B | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814051-A | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814041-A | Benzotriazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |