Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30285319 | 0.87 | NOD1 (0.61) | CA12CA9CA2ALDH1A1LMNA | |
| SCHEMBL3563271 | 0.81 | CA12 (0.56) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL28228343 | 0.81 | CA12 (0.56) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL4121234 | 0.80 | CCR2 (0.72) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL6864420 | 0.80 | ALDH1A1 (0.73) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL6864332 | 0.80 | RECQL (0.73) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL31599460 | 0.80 | CCR2 (0.72) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL5179816 | 0.79 | CA12 (0.55) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL10291046 | 0.79 | CA12 (0.55) | CA12CA9CA2SRCALDH1A1 | |
| SCHEMBL15668527 | 0.79 | CA12 (0.55) | CA12CA9CA2SRCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146469-A | Substituted oxindole derivatives and for treating the application of vasopressin-dependent disease | ABBVIE德国有限责任两合公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-101959878-B | Substituted oxindole derivatives and their use for the treatment of vasopressin dependent diseases | ABBVIE德国有限责任两合公司 | 2016-08-03 | — | — | CN | disclosed |