Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | RECQL | P46063 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11750966 | 0.86 | ALDH1A1 (0.52) | TDP1KDM4EMAPTHSD17B10HIF1A | |
| SCHEMBL16648551 | 0.86 | ESR1 (0.41) | TDP1KDM4EMAPTRECQLMTOR | |
| SCHEMBL30708493 | 0.86 | ESR1 (0.41) | TDP1KDM4EMAPTRECQLMTOR | |
| SCHEMBL5609726 | 0.84 | UGT2B7 (0.44) | UGT2B7CYP2C19AKR1C3AKR1C2 | |
| SCHEMBL11588725 | 0.82 | ALDH1A1 (0.55) | TDP1KDM4EMAPTRECQLMTOR | |
| SCHEMBL3309320 | 0.81 | RXRA (0.43) | UGT2B7AKR1C3AKR1C2 | |
| SCHEMBL31085167 | 0.81 | UGT2B7 (0.41) | LMNAUGT2B7TAS2R14AKR1C3AKR1C2 | |
| SCHEMBL17025358 | 0.81 | UGT2B7 (0.41) | LMNAUGT2B7TAS2R14AKR1C3AKR1C2 | |
| SCHEMBL31085127 | 0.81 | RXRA (0.43) | UGT2B7AKR1C3AKR1C2 | |
| SCHEMBL28853162 | 0.80 | AKR1C3 (0.48) | HSD17B1HSD17B2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105492437-A | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | KARYOPHARM THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |