Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16978292 | 0.80 | KCNH2 (0.42) | APPKCNH2TMEM97SIGMAR1ERN1 | |
| SCHEMBL8778326 | 0.79 | MAOB (0.54) | APPKCNH2TMEM97SIGMAR1EPHX2 | |
| SCHEMBL2097133 | 0.78 | APP (0.49) | APPKCNH2TMEM97SIGMAR1EPHX2 | |
| SCHEMBL14121378 | 0.78 | APP (0.49) | APPKCNH2TMEM97SIGMAR1EPHX2 | |
| SCHEMBL4849499 | 0.78 | APP (0.49) | APPKCNH2TMEM97SIGMAR1 | |
| SCHEMBL20309112 | 0.78 | EPHX2 (0.39) | KCNH2TMEM97SIGMAR1TRPV1EPHX2 | |
| SCHEMBL20309036 | 0.76 | NOTUM (0.37) | TRPV1EPHX2 | |
| SCHEMBL20309114 | 0.76 | TRPV1 (0.32) | TRPV1EPHX2 | |
| SCHEMBL213780 | 0.76 | MAOA (0.49) | APPKCNH2TMEM97SIGMAR1ERN1 | |
| SCHEMBL20309113 | 0.76 | NOTUM (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105492437-A | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | KARYOPHARM THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |