Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15934280 | 0.86 | TSHR (0.42) | APPCA1CA2PDE10AALOX5 | |
| SCHEMBL9367414 | 0.83 | GAA (0.40) | APPCASP1ALOX15HSD17B10KDM4E | |
| SCHEMBL8778326 | 0.81 | MAOB (0.54) | APPALOX15HSD17B10ALDH1A1CYP2C9 | |
| SCHEMBL6310104 | 0.81 | GAA (0.39) | APPCASP1ALOX15HSD17B10KDM4E | |
| SCHEMBL714264 | 0.81 | TSHR (0.48) | APPALDH1A1CYP3A4TDP1TSHR | |
| SCHEMBL31533760 | 0.81 | GAA (0.39) | APPCASP1ALOX15HSD17B10KDM4E | |
| SCHEMBL734531 | 0.79 | IDO1 (0.40) | TSHRGLAPOLBGAAMAPK1 | |
| SCHEMBL2097133 | 0.79 | APP (0.49) | APPMEN1KMT2AKCNH2TMEM97 | |
| SCHEMBL14121378 | 0.79 | APP (0.49) | APPKCNH2TMEM97SIGMAR1 | |
| SCHEMBL325072 | 0.78 | GAA (0.36) | APPALOX15HSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358397-B2 | Preparation of halogenated 4-aminophenols | LANXESS DEUTSCHLAND GMBH (DE) | 2008-04-15 | — | — | US | claimed |
| US-20050143425-A1 | Preparation of halogenated 4-aminophenols | LANXESS DEUTSCHLAND GMBH (DE) | 2005-06-30 | — | — | US | claimed |
| CN-1616412-A | Process for the preparation of halogen containing 4-amino phenols | BAYER CHEMICALS AG (DE) | 2005-05-18 | — | — | CN | claimed |
| EP-1514865-A1 | Process for the preparation of halogen containing 4-amino phenols | Bayer Chemicals AG (DE) | 2005-03-16 | — | — | EP | claimed |
| US-20230089368-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES S.A.S. (FR) | 2023-03-23 | — | — | US | disclosed |
| EP-3999057-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES SAS (FR) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |
| EP-3638670-B1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES AS MAP4K1 MODULATORS FOR THE TREATMENT OF CANCER DISEASES | Bayer Pharma AG (DE) | 2021-07-21 | — | — | EP | disclosed |
| WO-2021013712-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES S.A.S. (FR) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021013712-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES S.A.S. (FR) | 2021-01-28 | — | — | WO | disclosed |
| EP-3638670-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES AS MAP4K1 MODULATORS FOR THE TREATMENT OF CANCER DISEASES | Bayer Pharma Aktiengesellschaft (DE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018228923-A1 | SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES AS MAP4K1 MODULATORS FOR THE TREATMENT OF CANCER DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-12-20 | — | — | WO | disclosed |
| US-8604065-B2 | Pyridyl cyanoguanidine derivatives | Zhang, Hesheng (CN) | 2013-12-10 | — | — | US | disclosed |
| US-20120309797-A1 | PYRIDYL CYANOGUANIDINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) | 2012-12-06 | — | — | US | disclosed |
| US-20080139795-A1 | Preparation of halogenated 4-aminophenols | LANXESS DEUTSCHLAND GMBH (DE) | 2008-06-12 | — | — | US | disclosed |
| US-7358397-B2 | Preparation of halogenated 4-aminophenols | LANXESS DEUTSCHLAND GMBH (DE) | 2008-04-15 | — | — | US | disclosed |
| US-20050143425-A1 | Preparation of halogenated 4-aminophenols | LANXESS DEUTSCHLAND GMBH (DE) | 2005-06-30 | — | — | US | disclosed |
| CN-1616412-A | Process for the preparation of halogen containing 4-amino phenols | BAYER CHEMICALS AG (DE) | 2005-05-18 | — | — | CN | disclosed |
| EP-1514865-A1 | Process for the preparation of halogen containing 4-amino phenols | Bayer Chemicals AG (DE) | 2005-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230089368-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | CKMT1A; CKMT1B, TNNC1, UBQLN2 | APP 2330/4885CA1 4765/4885CA2 4350/4885 |
| US-20080139795-A1 | Preparation of halogenated 4-aminophenols | CYP4X1, CYP4B1, PAH | APP 3217/4885CA1 4498/4885CA2 3712/4885 |
| US-20050143425-A1 | Preparation of halogenated 4-aminophenols | CYP4X1, HPD, CYP4F8 | APP 3539/4885CA1 4576/4885CA2 3410/4885 |
| US-20120309797-A1 | PYRIDYL CYANOGUANIDINE DERIVATIVES | PNPO, XDH, PDXK | APP 4105/4885CA1 3405/4885CA2 1674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.