Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28101301 | 0.93 | LOX (0.37) | GAAG6PDL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29293752 | 0.78 | F2 (0.34) | ADRB1GAAALDH1A1MAPTTDP1 | |
| SCHEMBL17270065 | 0.78 | ADRB1 (0.51) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| SCHEMBL23392248 | 0.73 | ALOX5 (0.41) | GAAL3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL21254123 | 0.71 | ADRB1 (0.38) | ADRB1TSHRL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7798882 | 0.67 | GAA (0.42) | GAAUSP2G6PDL3MBTL1KDM4E | |
| Toluene SCHEMBL11325202 | 0.63 | ACHE (0.65) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| Toluene SCHEMBL5320366 | 0.63 | ACHE (0.65) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| SCHEMBL29327306 | 0.62 | HTR2C (0.51) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| SCHEMBL27777689 | 0.62 | HTR2C (0.51) | ADRB1SIGMAR1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103477463-B | Organic illuminating element, organometallic complex, light-emitting device, electronic equipment and illuminator | 株式会社半导体能源研究所 | 2016-08-10 | — | — | CN | disclosed |