SCHEMBL28061321

SCHEMBL28061321

O=C(Cc1ccccc1F)c1ccc(Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
MAPK1 P28482 1/20 0.49
GSK3B P49841 3/20 0.48
KMT2A Q03164 4/20 0.46
KDM4E B2RXH2 2/20 0.46
LMNA P02545 1/20 0.46
TSHR P16473 1/20 0.46
MPI P34949 1/20 0.46
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
RAB9A P51151 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL70282 0.85 MAPK1 (0.54) ALDH1A1MAPK1GSK3BKMT2AKDM4E
SCHEMBL29533518 0.85 MAPK1 (0.54) ALDH1A1MAPK1GSK3BKMT2AKDM4E
SCHEMBL7265238 0.83 ALDH1A1 (0.49) ALDH1A1MAPK1KMT2ALMNARAB9A
SCHEMBL6202500 0.83 L3MBTL1 (0.59) ALDH1A1MAPK1GSK3BKMT2AKDM4E
SCHEMBL8026821 0.79 GSK3B (0.48) ALDH1A1MAPK1GSK3BKMT2ALMNA
SCHEMBL3282677 0.79 ALDH1A1 (0.53) ALDH1A1MAPK1GSK3BKMT2ALMNA
SCHEMBL27917765 0.79 ALDH1A1 (0.51) ALDH1A1MAPK1GSK3BKMT2ALMNA
SCHEMBL11146926 0.79 GSK3B (0.48) ALDH1A1MAPK1GSK3BKMT2ALMNA
SCHEMBL27892309 0.78 AKR1C3 (0.57) ALDH1A1MAPK1GSK3BLMNATSHR
SCHEMBL11146921 0.78 HDAC3 (0.49) ALDH1A1GSK3BKMT2ALMNAHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105481794-A Organic white light material with thermal activation delay and aggregation-induced emission performance and synthetic method and application thereof UNIV SUN YAT SEN 2016-04-13 CN claimed
CN-105481794-A Organic white light material with thermal activation delay and aggregation-induced emission performance and synthetic method and application thereof UNIV SUN YAT SEN 2016-04-13 CN disclosed