Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29533518 | 0.85 | MAPK1 (0.54) | L3MBTL1MAPTTDP1RAB9AALDH1A1 | |
| SCHEMBL70282 | 0.85 | MAPK1 (0.54) | L3MBTL1MAPTTDP1RAB9AALDH1A1 | |
| SCHEMBL7265238 | 0.83 | ALDH1A1 (0.49) | L3MBTL1MAPTTDP1RAB9AALDH1A1 | |
| SCHEMBL28061321 | 0.83 | ALDH1A1 (0.49) | MAPTRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL2085224 | 0.82 | L3MBTL1 (0.62) | L3MBTL1MAPTRAB9ANPC1CNR1 | |
| SCHEMBL1025697 | 0.81 | MAPT (0.56) | L3MBTL1MAPTRAB9ANPC1CNR1 | |
| SCHEMBL17459291 | 0.80 | KMT2A (0.53) | L3MBTL1MAPTTDP1RAB9ACNR1 | |
| SCHEMBL3282677 | 0.79 | ALDH1A1 (0.53) | L3MBTL1RAB9AALDH1A1MAPK1GSK3B | |
| SCHEMBL2571844 | 0.78 | L3MBTL1 (0.62) | L3MBTL1MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL10046960 | 0.77 | ALDH1A1 (0.51) | L3MBTL1MAPTTDP1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
| US-5532374-A | Method of preparation of bis-quinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |