Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613370 | 0.81 | DDB1 (0.31) | — | |
| SCHEMBL28061555 | 0.78 | JAK2 (0.37) | P2RY1KCNH2 | |
| SCHEMBL28061550 | 0.75 | HTR2C (0.42) | — | |
| SCHEMBL28061557 | 0.74 | JAK2 (0.34) | PROKR1P2RY1KCNH2 | |
| SCHEMBL28061578 | 0.74 | JAK2 (0.34) | PROKR1P2RY1KCNH2 | |
| SCHEMBL14893608 | 0.72 | AVPR1A (0.47) | GPR119PROKR1MAPT | |
| SCHEMBL28061558 | 0.70 | HTR2A (0.40) | — | |
| SCHEMBL28061588 | 0.70 | HTR2A (0.40) | — | |
| SCHEMBL28242873 | 0.70 | RBP4 (0.41) | RBP4SCDPROKR1MAPTP2RY1 | |
| SCHEMBL16689567 | 0.70 | RBP4 (0.76) | RBP4SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693645-B | Condensed heterocyclic compouds as ion channel modulators | 吉利德科学公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-105693645-A | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | 吉利德科学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649056-B | Fused heterocyclic compounds as modulators of ion channels | GILEAD SCIENCES, INC. (US) | 2016-04-27 | — | — | CN | disclosed |