Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 5/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061650 | 0.87 | TMEM97 (0.35) | TBXAS1TMEM97SIGMAR1TBXA2R | |
| SCHEMBL28061679 | 0.87 | P2RX3 (0.40) | MAOB | |
| SCHEMBL28067355 | 0.85 | MMP9 (0.44) | CCR5 | |
| SCHEMBL28124735 | 0.84 | HCRTR2 (0.38) | TBXAS1CCR5TMEM97SIGMAR1TBXA2R | |
| SCHEMBL28125140 | 0.82 | GLA (0.43) | LTB4RLTB4R2SLC2A1 | |
| SCHEMBL27809084 | 0.76 | EGFR (0.39) | TBXAS1TMEM97SIGMAR1TBXA2RMAOB | |
| SCHEMBL28061646 | 0.76 | KDM4E (0.38) | TMEM97SIGMAR1 | |
| SCHEMBL28093132 | 0.76 | SMN1; SMN2 (0.39) | TBXAS1 | |
| SCHEMBL28294382 | 0.71 | TBXA2R (0.32) | TBXAS1TBXA2R | |
| SCHEMBL28331791 | 0.66 | MAPK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829294-B | The quinolyl conditioning agent of ROR- γ-T being connect with methylene | 詹森药业有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105873439-A | Alkyl-linked quinolinyl modulators of ROR γ t | 詹森药业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105829294-A | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | 詹森药业有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105636952-A | Secondary alcohol quinolinyl modulators of roryt | JANSSEN PHARMACEUTICA NV | 2016-06-01 | — | — | CN | disclosed |