Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.57 |
| ▸ | ABL1 | P00519 | 7/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.57 |
| ▸ | BCR | P11274 | 4/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28827455 | 0.86 | HDAC1 (0.61) | HDAC1ABL1HDAC3HDAC2HDAC8 | |
| SCHEMBL28062146 | 0.86 | HDAC1 (0.58) | HDAC1ABL1HDAC3HDAC2HDAC8 | |
| SCHEMBL28062149 | 0.81 | HDAC1 (0.63) | HDAC1ABL1HDAC3HDAC2HDAC8 | |
| SCHEMBL27950841 | 0.81 | TRPM5 (0.37) | HDAC1ABL1HDAC3HDAC2HDAC8 | |
| SCHEMBL27937288 | 0.78 | AURKA (0.44) | HDAC1ABL1HDAC3HDAC2HDAC8 | |
| SCHEMBL28062184 | 0.69 | JAK3 (0.47) | — | |
| SCHEMBL28062112 | 0.68 | AURKA (0.54) | LCK | |
| SCHEMBL2733418 | 0.66 | HDAC1 (0.64) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27937318 | 0.66 | ALDH1A1 (0.42) | HDAC1HDAC3HDAC2HDAC6KDR | |
| SCHEMBL27950831 | 0.64 | CDC7 (0.51) | LCKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103539793-B | Thiazole carboxamides compounds and application thereof | 南京圣和药业股份有限公司 | 2016-06-08 | — | — | CN | disclosed |