Benzoic Acid

Benzoic Acid

SCHEMBL2806428

CC1CCC(C)CC1.O=C(O)c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.64
DAO P14920 1/20 0.64
NAPRT Q6XQN6 1/20 0.64
ACHE P22303 1/20 0.58
USP2 O75604 1/20 0.56
CES2 O00748 2/20 0.54
CES1 P23141 2/20 0.54
SRD5A2 P31213 1/20 0.54
TP53 P04637 1/20 0.48
PLA2G1B P04054 1/20 0.47
ATG4B Q9Y4P1 1/20 0.47
CYP2C8 P10632 1/20 0.47
CYP2C9 P11712 1/20 0.47
LMNA P02545 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
MAPK1 P28482 1/20 0.45
HSP90AA1 P07900 1/20 0.45
ALDH1A1 P00352 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzoic Acid SCHEMBL4089889 0.94 TSHR (0.56) TSHRDAONAPRTACHEUSP2
Benzoic Acid SCHEMBL4089426 0.91 TSHR (0.58) TSHRDAONAPRTACHEUSP2
Terephthalic Acid SCHEMBL301905 0.91 USP2 (0.66) TSHRDAONAPRTACHEUSP2
Benzoic Acid SCHEMBL4088807 0.90 TSHR (0.56) TSHRDAONAPRTACHEUSP2
Benzoic Acid SCHEMBL4098363 0.90 TSHR (0.56) TSHRDAONAPRTACHEUSP2
Terephthalic Acid SCHEMBL11843372 0.84 USP2 (0.59) TSHRDAONAPRTACHEUSP2
Benzoic Acid SCHEMBL27819561 0.83 TSHR (0.58) TSHRDAONAPRTACHEUSP2
Phthalic Acid SCHEMBL22471697 0.82 ALDH1A1 (0.64) NAPRTACHEMEN1KMT2ASMN1; SMN2
SCHEMBL8260835 0.81 ACHE (0.53) ACHEMEN1KMT2ASMN1; SMN2ALDH1A1
Benzoic Acid SCHEMBL10457491 0.80 TSHR (0.88) TSHRDAONAPRTCES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2221320-B1 SOLID TITANIUM CATALYST INGREDIENT, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD OF POLYMERIZING OLEFIN MITSUI CHEMICALS INC (JP) 2017-06-21 EP disclosed
US-8822366-B2 Solid titanium catalyst component, catalyst for olefin polymerization and process for polymerizing olefin MITSUI CHEMICALS, INC. (JP) 2014-09-02 US disclosed
US-8742040-B2 Solid titanium catalyst component, olefin polymerization catalyst, and olefin polymerization process MITSUI CHEMICALS, INC. (JP) 2014-06-03 US disclosed
EP-2048166-B1 SOLID TITANIUM CATALYST INGREDIENT, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD OF OLEFIN POLYMERIZATION MITSUI CHEMICALS INC (JP) 2014-02-26 EP disclosed
EP-2206731-B1 SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD MITSUI CHEMICALS INC (JP) 2013-08-28 EP disclosed
CN-101874046-B Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of polymerizing olefin MITSUI CHEMICALS INC 2013-03-20 CN disclosed
CN-101490101-B Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of olefin polymerization MITSUI CHEMICALS INC 2011-11-02 CN disclosed
US-20100305285-A1 SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION PROCESS MITSUI CHEMICALS, INC. 2010-12-02 US disclosed
CN-101874046-A Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of polymerizing olefin MITSUI CHEMICALS INC 2010-10-27 CN disclosed
US-20100227991-A1 SOLID TITANIUM CATALYST COMPONENT, CATALIST FOR OLEFIN POLYMERIZATION AND PROCESS FOR POLYMERIZING OLEFIN MITSUI CHEMICALS, INC. (JP) 2010-09-09 US disclosed
EP-2221320-A1 SOLID TITANIUM CATALYST INGREDIENT, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD OF POLYMERIZING OLEFIN Mitsui Chemicals, Inc. (JP) 2010-08-25 EP disclosed
EP-2206731-A1 SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION METHOD Mitsui Chemicals, Inc. (JP) 2010-07-14 EP disclosed
US-20090203855-A1 Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of olefin polymerization MITSUI CHEMICALS, INC. 2009-08-13 US disclosed
CN-101490101-A Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of olefin polymerization MITSUI CHEMICALS INC (JP) 2009-07-22 CN disclosed
EP-2048166-A1 SOLID TITANIUM CATALYST INGREDIENT, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD OF OLEFIN POLYMERIZATION Mitsui Chemicals, Inc. (JP) 2009-04-15 EP disclosed