Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | DDO | Q99489 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571726 | 0.85 | GRM2 (0.48) | HRH4RIPK1MEN1KMT2AMAPK1 | |
| SCHEMBL30555176 | 0.81 | RIPK1 (0.37) | HRH4RIPK1DAODDOMEN1 | |
| SCHEMBL7942068 | 0.81 | HRH4 (0.57) | HRH4DAODDOMEN1USP2 | |
| SCHEMBL29990795 | 0.81 | EIF4A3 (0.48) | HRH4MEN1USP2ALDH1A1HPGD | |
| SCHEMBL24074547 | 0.79 | GRM2 (0.44) | HRH4MEN1USP2ALDH1A1HPGD | |
| SCHEMBL30494448 | 0.78 | HPGD (0.53) | HRH4RIPK1DAODDOMEN1 | |
| SCHEMBL29053576 | 0.78 | HPGD (0.53) | HRH4RIPK1DAODDOMEN1 | |
| SCHEMBL30494484 | 0.77 | HPGD (0.46) | RIPK1DAOMEN1USP2ALDH1A1 | |
| SCHEMBL28064535 | 0.77 | HPGD (0.46) | RIPK1DAOMEN1USP2ALDH1A1 | |
| SCHEMBL28064557 | 0.73 | HDAC11 (0.47) | HRH4MAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | claimed |
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | disclosed |