Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064624 | 0.86 | BTK (0.42) | MCL1JAK2BTKTSHRKDM4E | |
| SCHEMBL28064659 | 0.81 | MCL1 (0.50) | MCL1GPR35TSHRKDM4EL3MBTL1 | |
| SCHEMBL23809174 | 0.78 | MCL1 (0.45) | MCL1GPR35TSHRKDM4EL3MBTL1 | |
| SCHEMBL24756083 | 0.77 | GPR35 (0.45) | MCL1GPR35KDM4EL3MBTL1MEN1 | |
| SCHEMBL28207997 | 0.74 | MEN1 (0.45) | MCL1GPR35TSHRKDM4EL3MBTL1 | |
| SCHEMBL28064572 | 0.74 | BTK (0.40) | JAK2BTKKDM4ENPC1RAB9A | |
| SCHEMBL30639179 | 0.73 | KDM4E (0.67) | MCL1TSHRKDM4EL3MBTL1MEN1 | |
| SCHEMBL1092586 | 0.73 | KDM4E (0.67) | MCL1TSHRKDM4EL3MBTL1MEN1 | |
| SCHEMBL28792536 | 0.71 | HTR2C (0.47) | MCL1 | |
| SCHEMBL7269233 | 0.69 | PCSK9 (0.52) | KDM4EL3MBTL1RORCCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | disclosed |