Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CFB | P00751 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24367203 | 0.87 | KMT2A (0.48) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL16401017 | 0.87 | KMT2A (0.48) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| Tert-Butyl Formate SCHEMBL28065167 | 0.86 | CA1 (0.37) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL2911688 | 0.83 | CA2 (0.47) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL24364070 | 0.77 | KMT2A (0.48) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| Tert-Butyl Formate SCHEMBL28024916 | 0.76 | SLC6A3 (0.39) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL17782325 | 0.73 | KMT2A (0.44) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL24364058 | 0.73 | KMT2A (0.44) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| SCHEMBL17538757 | 0.73 | CHRNB2 (0.46) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 | |
| Tert-Butyl Formate SCHEMBL28064954 | 0.72 | MEN1 (0.37) | MEN1KMT2ACYP2D6CYP2C19CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-105579444-A | Piperidinylindole derivatives and their use as complement factor B inhibitors | NOVARTIS AG | 2016-05-11 | — | — | CN | disclosed |