Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 17/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065026 | 0.79 | RIPK1 (0.44) | RIPK1HRH3CFBKDM1A | |
| SCHEMBL28065036 | 0.78 | RIPK1 (0.43) | RIPK1KDM1A | |
| SCHEMBL25619905 | 0.76 | TSHR (0.45) | — | |
| SCHEMBL28063655 | 0.75 | RIPK1 (0.48) | RIPK1 | |
| SCHEMBL28064896 | 0.75 | RIPK1 (0.48) | RIPK1HRH3 | |
| SCHEMBL28209962 | 0.75 | RIPK1 (0.48) | RIPK1HRH3MAOA | |
| SCHEMBL28104994 | 0.75 | — | — | |
| SCHEMBL17782223 | 0.74 | RIPK1 (0.50) | RIPK1KDM1A | |
| SCHEMBL27971288 | 0.74 | RIPK1 (0.42) | RIPK1KDM1AMAOA | |
| SCHEMBL27801641 | 0.73 | SLC6A2 (0.46) | RIPK1HRH3KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-105579444-A | Piperidinylindole derivatives and their use as complement factor B inhibitors | NOVARTIS AG | 2016-05-11 | — | — | CN | disclosed |