Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.44 |
| ▸ | CFB | P00751 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065027 | 0.79 | RIPK1 (0.50) | RIPK1CFBKDM1AHRH3 | |
| SCHEMBL16409384 | 0.78 | RIPK1 (0.44) | RIPK1CFB | |
| SCHEMBL16400851 | 0.76 | CFB (0.46) | RIPK1CFBKDM1A | |
| SCHEMBL28858375 | 0.72 | CFB (0.58) | RIPK1CFBKDM1A | |
| SCHEMBL28065036 | 0.72 | RIPK1 (0.43) | RIPK1KDM1A | |
| SCHEMBL27807760 | 0.72 | MEN1 (0.35) | — | |
| SCHEMBL20011760 | 0.72 | CFB (0.43) | RIPK1CFBKDM1A | |
| SCHEMBL28065018 | 0.71 | RIPK1 (0.41) | RIPK1HRH3 | |
| SCHEMBL28063655 | 0.70 | RIPK1 (0.48) | RIPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28064896 | 0.70 | RIPK1 (0.48) | RIPK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-A | Piperidinylindole derivatives and their use as complement factor B inhibitors | NOVARTIS AG | 2016-05-11 | — | — | CN | disclosed |