Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.73 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.73 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.73 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SI | P14410 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.59 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135495 | 0.84 | CSNK2A2 (0.69) | CSNK2A2CSNK2BCSNK2A1MCL1ALDH1A1 | |
| SCHEMBL27986597 | 0.84 | CSNK2A2 (1.00) | CSNK2A2CSNK2BCSNK2A1METMCL1 | |
| SCHEMBL5351976 | 0.79 | MET (1.00) | METMCL1ALDH1A1GAAKDM4E | |
| SCHEMBL1594333 | 0.79 | CSNK2A2 (0.61) | CSNK2A2CSNK2BCSNK2A1MCL1ALDH1A1 | |
| 4-Methyldaphnetin SCHEMBL1065373 | 0.75 | MCL1 (1.00) | METMCL1ALDH1A1GAAKDM4E | |
| 4-Methyldaphnetin SCHEMBL29671915 | 0.75 | MCL1 (1.00) | METMCL1ALDH1A1GAAKDM4E | |
| SCHEMBL15842835 | 0.75 | CYP1A2 (0.56) | CSNK2A2CSNK2BCSNK2A1MCL1ALDH1A1 | |
| SCHEMBL1448400 | 0.74 | ERAP1 (0.69) | CSNK2A2CSNK2BCSNK2A1MCL1ALDH1A1 | |
| SCHEMBL18460961 | 0.74 | MAOB (0.63) | CSNK2A2CSNK2BCSNK2A1MCL1ALDH1A1 | |
| SCHEMBL8570582 | 0.73 | CSNK2A2 (0.51) | CSNK2A2CSNK2BCSNK2A1METMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105566269-A | Preparation and pharmacological effects of coumarin derivative and application of coumarin derivative to treatment on pruritus | UNIV BEIJING | 2016-05-11 | — | — | CN | disclosed |
| CN-105524034-A | Preparation method of coumarin derivative, pharmacological effect of coumarin derivative and use of coumarin derivative in treatment on cerebral ischemia | UNIV BEIJING | 2016-04-27 | — | — | CN | disclosed |
| CN-105524034-A | Preparation method of coumarin derivative, pharmacological effect of coumarin derivative and use of coumarin derivative in treatment on cerebral ischemia | UNIV BEIJING | 2016-04-27 | — | — | CN | disclosed |