4-Methyldaphnetin

4-Methyldaphnetin

SCHEMBL1065373

Cc1cc(=O)oc2c(O)c(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 5/20 1.00
GAA P10253 2/20 1.00
KDM4E B2RXH2 1/20 1.00
MGAM O43451 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
TP53 P04637 1/20 1.00
CYP3A4 P08684 1/20 1.00
MAPT P10636 1/20 1.00
SI P14410 1/20 1.00
ALOX15 P16050 1/20 1.00
MAPK1 P28482 1/20 1.00
MGAM2 Q2M2H8 1/20 1.00
MAOB P27338 7/20 0.75
MET P08581 1/20 0.71
GFER P55789 1/20 0.71
HSD17B10 Q99714 1/20 0.71
ERN1 O75460 1/20 0.69
MAOA P21397 3/20 0.67
ATP1A1 P05023 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Methyldaphnetin SCHEMBL29671915 1.00 MCL1 (1.00) MCL1GAAKDM4EMGAMALDH1A1
4-Methyldaphnetin SCHEMBL1668524 0.89 MCL1 (0.80) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL4187220 0.86 MAOB (1.00) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL5351976 0.83 MET (1.00) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL23143160 0.83 MAOB (0.71) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL8724340 0.83 GAA (1.00) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL10627951 0.83 MAOB (0.71) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL9464086 0.83 MAOB (0.71) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL12858749 0.82 MCL1 (0.69) MCL1GAAKDM4EMGAMALDH1A1
SCHEMBL14398970 0.81 ERN1 (1.00) MCL1GAAKDM4EMGAMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304727-A1 PHOTOINITIATOR PACKAGE COMPRISING PHOSPHINE OXIDE PHOTOINITIATORS, COUMARIN-BASED SENSITIZERS AND AMINE ADDITIVES IGM GROUP B.V. (NL) 2025-10-02 US claimed
US-12421419-B2 Preparation method for ultraviolet-responsive coumarin controlled-release and self-repairing anti-fouling paint Quzhou Research Institute of Zhejiang University (CN) 2025-09-23 US claimed
US-20250109444-A1 DNA HYPOMETHYLATION AS A PREDICTIVE MARKER FOR CANCER THERAPY FRED HUTCHINSON CANCER CENTER (US) 2025-04-03 US claimed
EP-4519376-A1 PHOTOINITIATOR PACKAGE COMPRISING PHOSPHINE OXIDE PHOTOINITIATORS, COUMARIN-BASED SENSITIZERS AND AMINE ADDITIVES IGM Group B.V. (NL) 2025-03-12 EP claimed
CN-118319988-A A flos Carthami composition effective component extract and its preparation method 广西壮族自治区花红药业集团股份公司 2024-07-12 CN claimed
CN-118325263-A Conductive hydrogel film with glucose response and preparation method and application thereof 重庆医科大学 2024-07-12 CN claimed
WO-2024047248-A1 USE OF NRF2 ACTIVATORS FOR THE TREATMENT OF CEREBRAL SMALL VESSEL DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2024-03-07 WO claimed
CN-117285823-A Biological conductive material containing sericin, preparation method and application 重庆市铜梁区人民医院 2023-12-26 CN claimed
WO-2023214013-A1 PHOTOINITIATOR PACKAGE COMPRISING PHOSPHINE OXIDE PHOTOINITIATORS, COUMARIN-BASED SENSITIZERS AND AMINE ADDITIVES IGM GROUP B. V. (NL) 2023-11-09 WO claimed
CN-115851110-B Preparation method of light response long-acting super-lubricating anti-fouling paint based on coumarin 浙江大学 2023-08-15 CN claimed
US-7838186-B2 Photoconductors containing charge transport chelating components XEROX CORPORATION (US) 2010-11-23 US claimed
US-20080286670-A1 Photoconductors containing charge transport chelating components XEROX CORPORATION 2008-11-20 US claimed
EP-1282411-A4 METHOD OF TREATING CANCER CHARLOTTE MECKLENBURG HOSPITAL (US) 2008-05-21 EP claimed
US-20080009544-A1 Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-01-10 US claimed
US-20070142462-A1 Method of Treating Cancer THE UNIVERSITY OF UTAH 2007-06-21 US claimed
WO-2006024545-A1 FUSED BICYCLIC NATURAL COMPOUNDS AND THEIR USE AS INHIBITORS OF PARP AND PARP-MEDIATED INFLAMMATORY PROCESSES STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2006-03-09 WO claimed
US-20040047852-A1 Method of treating cancer THE UNIVERSITY OF UTAH 2004-03-11 US claimed
EP-1282411-A1 METHOD OF TREATING CANCER Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) 2003-02-12 EP claimed
WO-2001080849-A1 METHOD OF TREATING CANCER CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS MEDICAL CENTER (US) 2001-11-01 WO claimed
WO-1996031206-A2 FLAVONES AND COUMARINS AS AGENTS FOR THE TREATMENT OF ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1996-10-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250109444-A1 DNA HYPOMETHYLATION AS A PREDICTIVE MARKER FOR CANCER THERAPY DNMT1, DNMT3B, DNMT3A MCL1 133/4885GAA 2743/4885KDM4E 656/4885
US-20080009544-A1 Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors ACHE, BCHE, CHRNB1 MCL1 4551/4885GAA 489/4885KDM4E 1482/4885
US-20040047852-A1 Method of treating cancer CAT, SOD3, SOD1 MCL1 697/4885GAA 179/4885KDM4E 4084/4885
US-20070142462-A1 Method of Treating Cancer CAT, SOD3, SOD1 MCL1 697/4885GAA 179/4885KDM4E 4084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.