Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17151506 | 0.77 | PDE3B (0.47) | PDE3BPDE3ARAB9AMAPK14MAPK11 | |
| SCHEMBL4750216 | 0.77 | GRIA1 (0.40) | RAB9AJAK2RPS6KA3MELKMAPK14 | |
| SCHEMBL14771286 | 0.70 | CHEK1 (0.49) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL723954 | 0.68 | AHR (0.47) | PDE3BPDE3AMAPK14BCHEEGFR | |
| SCHEMBL4750235 | 0.68 | RAD51 (0.43) | RAB9AJAK2RPS6KA3MELKMAPK14 | |
| SCHEMBL27418449 | 0.67 | JAK2 (0.41) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL28399234 | 0.67 | JAK2 (0.45) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL4148219 | 0.66 | PDE3B (0.47) | PDE3BPDE3ARAB9AMAPK14MAPK11 | |
| SCHEMBL723675 | 0.64 | PIK3CD (0.47) | PDE3BPDE3ABCHEGRIA1NPC1 | |
| SCHEMBL5983565 | 0.64 | JAK2 (0.41) | JAK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103159757-B | The synthetic method of one class 2,7-naphthyridines-1 (2H)-one | JIANGSU SIMCERE PHARMACEUTICAL RESEARCH COMPANY LIMITED (CN) | 2016-04-20 | — | — | CN | disclosed |