Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.79 |
| ▸ | GAA | P10253 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | HTT | P42858 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CASP6 | P55212 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MPI | P34949 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15285080 | 0.86 | KDM4E (0.61) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL31414410 | 0.86 | KDM4E (0.61) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2555897 | 0.81 | KDM4E (0.70) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL31060326 | 0.81 | KDM4E (0.70) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10791581 | 0.80 | KDM4E (0.69) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19236367 | 0.79 | KDM4E (0.79) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14756048 | 0.78 | KDM4E (0.53) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13479651 | 0.77 | KDM4E (1.00) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8745765 | 0.75 | KDM4E (0.65) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9318993 | 0.74 | PKLR (0.55) | KDM4EGAAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105566269-A | Preparation and pharmacological effects of coumarin derivative and application of coumarin derivative to treatment on pruritus | UNIV BEIJING | 2016-05-11 | — | — | CN | disclosed |
| CN-105524034-A | Preparation method of coumarin derivative, pharmacological effect of coumarin derivative and use of coumarin derivative in treatment on cerebral ischemia | UNIV BEIJING | 2016-04-27 | — | — | CN | disclosed |