Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.79 |
| ▸ | GAA | P10253 | 5/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | JAK2 | O60674 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | MPI | P34949 | 1/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.79 |
| ▸ | SHBG | P04278 | 1/20 | 0.63 |
| ▸ | NQO1 | P15559 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839705 | 0.89 | KDM4E (1.00) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL8745765 | 0.86 | KDM4E (0.65) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL2791744 | 0.85 | GAA (0.67) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL30969188 | 0.85 | NQO1 (0.64) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL31414410 | 0.84 | KDM4E (0.61) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL15285080 | 0.84 | KDM4E (0.61) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL28065533 | 0.79 | KDM4E (0.56) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL28065536 | 0.79 | KDM4E (0.79) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL28065504 | 0.79 | ESR2 (0.56) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL29157679 | 0.77 | ESR2 (0.71) | KDM4EGAAMAPTMAPK1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |