Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27527224 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ANR4A2CASP1 | |
| SCHEMBL24971013 | 0.80 | CASP6 (0.52) | TDP1ALDH1A1MEN1KMT2ANR4A2 | |
| SCHEMBL30903381 | 0.80 | CASP6 (0.52) | TDP1ALDH1A1MEN1KMT2ANR4A2 | |
| SCHEMBL22045250 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ANR4A2CASP1 | |
| SCHEMBL28107525 | 0.77 | TDP1 (0.46) | TDP1ALDH1A1MEN1KMT2ANR4A2 | |
| SCHEMBL28065792 | 0.77 | CASP6 (0.53) | TDP1ALDH1A1MEN1KMT2ANR4A2 | |
| SCHEMBL27864539 | 0.75 | SMN1; SMN2 (0.56) | TDP1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL1067857 | 0.74 | KDM4E (0.59) | TDP1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL31544472 | 0.74 | KDM4E (0.59) | TDP1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL25065371 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ACASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007125-B | fused heterocyclic derivatives and methods of use | AMGEN INC. (US) | 2016-05-25 | — | — | CN | disclosed |