SCHEMBL28066129

SCHEMBL28066129

O=C=NC(C(=O)O)c1ccc(O)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.43
SLC7A5 Q01650 1/20 0.39
ESR1 P03372 6/20 0.36
ESR2 Q92731 6/20 0.36
GRM8 O00222 1/20 0.36
GRM4 Q14833 1/20 0.36
ALDH1A1 P00352 2/20 0.36
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA3 P07451 1/20 0.35
TYR P14679 1/20 0.35
DRD1 P21728 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8627633 0.84 SRC (0.46) SRCTDP1CYP2C19GRM2
SCHEMBL3578270 0.84 SRC (0.46) SRCTDP1CYP2C19GRM2
SCHEMBL19337445 0.76 SRC (0.46) SRCSLC7A5ESR1ESR2GRM8
SCHEMBL10617868 0.75 ESR1 (0.41) SRCESR1ESR2ALDH1A1KMT2A
SCHEMBL7771355 0.69 SRC (0.47) SRCSLC7A5ESR1ESR2GRM8
SCHEMBL4727822 0.69 SLC7A5 (0.51) SLC7A5ESR1ESR2ALDH1A1KMT2A
SCHEMBL12483915 0.69 SLC7A5 (0.51) SLC7A5ESR1ESR2ALDH1A1KMT2A
Oxfenicine SCHEMBL122315 0.69 HSD17B10 (0.55) SRCSLC7A5ESR1ESR2GRM8
Oxfenicine SCHEMBL652186 0.69 HSD17B10 (0.55) SRCSLC7A5ESR1ESR2GRM8
Oxfenicine SCHEMBL124861 0.69 HSD17B10 (0.55) SRCSLC7A5ESR1ESR2GRM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105585510-A Synthesis method of hydroxylamine imidazole cephalosporin propylene glycol drug intermediate D-alpha-tert-butoxy carbonyl amino-alpha-(4-hydroxyphenyl)-acetic acid CHENGDU DONGDIAN AIER TECH CO LTD 2016-05-18 CN disclosed