Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 11/20 | 0.58 |
| ▸ | SYK | P43405 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28066927 | 0.91 | TNK2 (0.60) | TNK2SYKKDM4EKMT2AALDH1A1 | |
| SCHEMBL28066957 | 0.91 | TNK2 (0.60) | TNK2SYKALDH1A1JAK2SRC | |
| SCHEMBL28829103 | 0.82 | TNK2 (0.53) | TNK2KDM4EKMT2AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL28067024 | 0.76 | L3MBTL1 (0.45) | TNK2KDM4EKMT2AALDH1A1GAA | |
| SCHEMBL16453373 | 0.73 | TNK2 (1.00) | TNK2JAK2SRCALKCHEK1 | |
| SCHEMBL16453372 | 0.73 | TNK2 (1.00) | TNK2JAK2SRCALKCHEK1 | |
| SCHEMBL16453367 | 0.73 | TNK2 (1.00) | TNK2JAK2SRCALKCHEK1 | |
| SCHEMBL1028839 | 0.73 | DHFR (0.46) | — | |
| SCHEMBL2558872 | 0.73 | DHFR (0.60) | — | |
| Hydrochloric Acid SCHEMBL17838919 | 0.73 | TNK2 (0.98) | TNK2JAK2SRCALKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105592850-A | Inhibitors of ACK1/TNK2 tyrosine kinase | H LEE MOFFITT CANCER CT &RES | 2016-05-18 | — | — | CN | disclosed |