Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28066917 | 0.91 | TNK2 (0.58) | TNK2ALDH1A1MAPTCHEK1JAK2 | |
| SCHEMBL28066957 | 0.89 | TNK2 (0.60) | TNK2ALDH1A1CYP1A2CHEK1JAK2 | |
| SCHEMBL28829103 | 0.79 | TNK2 (0.53) | TNK2ALDH1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL16453378 | 0.75 | TNK2 (1.00) | TNK2CHEK1JAK2ABL1LCK | |
| SCHEMBL16447803 | 0.74 | TNK2 (1.00) | TNK2CHEK1JAK2ABL1LCK | |
| Hydrochloric Acid SCHEMBL28067024 | 0.74 | L3MBTL1 (0.45) | TNK2ALDH1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL30515653 | 0.72 | DHFR (0.56) | — | |
| SCHEMBL17907560 | 0.72 | DHFR (0.56) | — | |
| SCHEMBL1588124 | 0.70 | HRH4 (0.69) | TNK2ALDH1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL1589145 | 0.69 | HRH4 (0.68) | TNK2ALDH1A1CYP1A2MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105592850-A | Inhibitors of ACK1/TNK2 tyrosine kinase | H LEE MOFFITT CANCER CT &RES | 2016-05-18 | — | — | CN | disclosed |